Development of a longitudinal two-biomarker algorithm for early detection of ovarian cancer in women with BRCA mutations.

CONCLUSION: A newly developed two-marker ROCA administered every 4 months had lower call-back rates than SOC surveillance. Having established high specificity, the two-marker ROCA score deserves further evaluation for sensitivity in a larger trial.
PMID: 33012551 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - September 30, 2020 Category: Cancer & Oncology Authors: Lentz SE, Powell CB, Haque R, Armstrong MA, Anderson M, Liu Y, Jiang W, Chillemi G, Shaw S, Alvarado MM, Kushi LH, Skates SJ Tags: Gynecol Oncol Source Type: research