Corticosteroids for COVID-19, Emergency COVID-19 Vaccine Authorization, Influenza Vaccination, and more
Editor's Summary by Howard Bauchner, MD, Editor in Chief of JAMA, the Journal of the American Medical Association, for the October 6, 2020 issue
Comparison of deaths from the coronavirus (COVID-19) with deaths from influenza (flu) and pneumonia. Includes deaths by date of death occurrence and breakdowns by sex and age.
Since its emergence the impact of COVID-19 has been profound, and the public health challenge seem to be the most serious seen in a respiratory virus since the 1918 H1N1 influenza pandemic (Soper 1919). Following its emergence in Wuhan, cases of COVID-19 were exported outside of China, mainly by travelers using the global aviation networks (Wu et al., 2020). It should be noted that transboundary spread of viruses is quite common in veterinary medicine (Klausner et al., 2015, 2017, 2018).
The COVID-19 pandemic exerts inflammation-related parasympathetic complications and post-infection manifestations with major inter-individual variability. To seek the corresponding transcriptomic origins for the impact of COVID-19 infection and its aftermath consequences, we sought the relevance of long and short non-coding RNAs (ncRNAs) for susceptibility to COVID-19 infection. We selected inflammation-prone men and women of diverse ages among the cohort of Genome Tissue expression (GTEx) by mining RNA-seq datasets from their lung, and blood tissues, followed by quantitative qRT-PCR, bioinformatics-based network analyses ...
Authors: Campos L, Mansinho K, Telles de Freitas P, Ramos V, Sakellarides C Abstract The possibility of a second wave of the COVID-19 pandemic coexisting with a simultaneous epidemic of influenza and the co-circulation of other seasonal respiratory viruses sets the stage for a perfect storm. Preparing for the Autumn-Winter of 2020/2021 is complex, requiring centralized guidance but local and regional solutions, with strong leadership and a high level of coordination. It is essential to act upstream of hospitals in order to reduce demand on emergency departments, minimizing the risk of transmission that occurs there...
This study underscores the importance of regular hand washing and the use of hand sanitizer to prevent the spread of the coronavirus.
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus. Click arrow to playDownload TWiV 670 (76 MB .mp3, […]
Covid-19 was listed as the underlying cause of death for 48,168 fatalities between January and August this year in England and Wales, compared to 14,013 from pneumonia and influenza.
As America ’s biopharmaceutical companies work around the clock to combat COVID-19, another virus with deadly consequences is right around the corner. The COVID-19 pandemic has led to more than 7.5 million infections and tragically more than210,000 deaths. The influenza virus, more commonly known as the flu, is starting to circulate in the U.S. This year, already-strained health systems across the U.S. are preparing for a double whammy: flu season compounded by the ongoing COVID-19 pandemic.
The take-home message from this short review is that no population group is completely safe from COVID-19 at the present time, and there is no room for complacency. Dual infection with influenza this winter may be particularly problematic.
An enigmatic epidemiological feature of the ongoing COVID-19 pandemic is the high rate of asymptomatic infection in pregnant women.1 This is puzzling because systemic immune changes predispose pregnant women to increased severity of respiratory viral infections, especially influenza A.2 A major roadblock in understanding this atypical clinical presentation is the poor characterization of cellular entry factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) — angiotensin-converting enzyme 2 (ACE2) and the androgen-sensitive transmembrane protease serine 2 (TMPRSS2) — in the respiratory tract during pregnancy.