Predicting Heart Failure Events in Patients with Coronary Heart Disease and Impaired Glucose Tolerance: Insights from the Acarbose Cardiovascular Evaluation (ACE) trial

It is well known that individuals with type 2 diabetes (T2D) have a higher incidence of heart failure than those without.(1) Less is known, however, about the relationship between impaired glucose tolerance (IGT) and heart failure incidence, and whether treating IGT to delay or prevent development of T2D might reduce the incidence of heart failure. China has one of the highest rates of IGT and new-onset T2D in the world.(2) In addition, the China Heart Survey showed that the prevalence of IGT is significantly higher in individuals with coronary heart disease (CHD), compared with those without CHD.(3) Thus, the combination of CHD and IGT potentially identifies individuals at a greatly increased risk of developing heart failure.

Source: Diabetes Research and Clinical Practice - October 5, 2020 Category: Endocrinology Authors: Malgorzata Wamil, John J. V. McMurray, Charles A.B. Scott, Ruth L. Coleman, Yihong Sun, Eberhard Standl, Lars Ryd én, Rury R. Holman Source Type: research