Expressions of miR-302a, miR-105, and miR-888 Play Critical Roles in Pathogenesis, Radiotherapy, and Prognosis on Rectal Cancer Patients: A Study From Rectal Cancer Patients in a Swedish Rectal Cancer Trial of Preoperative Radiotherapy to Big Database Analyses
In this study, we used real-time polymerase chain reaction to examine the expressions of miR-302a, miR-105, and miR-888 in normal mucosa and cancer tissue from rectal cancer patients with and without preoperative RT. The biological function of miR-302a, miR-105, and miR-888 expression was further analyzed and identified through the public databases: TCGA (The Cancer Genome Atlas) and GEPIA (Gene Expression Profiling Interactive Analysis). The results showed that the expression of miR-105 in rectal cancer was higher than that in normal mucosa in RT (P = 0.042) and non-RT patients (P = 0.003) and was associated with mucinous histological type (P = 0.004), COX-2 (P = 0.042), and p73 expression (P = 0.030). The expression of miR-302a was shown more frequently in cancers with necrosis (P = 0.033) and with WRAP53 expression (P = 0.015), whereas miR-888 expression occurred more frequently in tumors with protein the expression of survivin (P = 0.015), AEG-1 (astrocyte elevated gene-1) (P = 0.003), and SATB1 (special AT-rich sequence binding protein 1) (P = 0.036). Moreover, TargetScan also predicted AEG-1 and SATB1 as putative targets for miR-888. The miRNA–gene network analysis showed that ABI2 was associated with all the three miRNAs, with lower expression and good diagnostic value in rectal cancers. The TCGA database demonstrated the association of miR-105 expression with high carcinoembryonic antigen level (P = 0.048). RT reduced the expressions of miR-302a, miR-105, and mi...
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Rita Peila, Rhonda S. Arthur, Thomas E. Rohan
ConclusionThis study suggests that multidisciplinary management is a potentially effective treatment strategy for isolated LNM. Since time to LNM, the T-stage, and histological type are prognostic factors, an active follow-up program for colorectal cancer is required.
ConclusionsApplication of pure transanal endoscopic colectomy without abdominal assistance to ACC appears to be feasible and safe.
CONCLUSIONS: Although the uptake and timeliness of chemotherapy for colorectal cancer has been improving, Māori, Pacific, Asian and older patients were less likely to receive chemotherapy and less likely to receive chemotherapy in a timely manner. There is a variation in use of chemotherapy by Region with patients in the Southern Cancer region appearing to be the most likely to receive chemotherapy and to receive it within a timely period. PMID: 32994590 [PubMed - in process]
Operation is the standard of care after neoadjuvant chemoradioterapy. Therefore a nonoperative management (W&W) has been proposed as an option for patients who achieve a complete clinical response by exclusive chemoradiotherapy. This approach is still investigational and we compared outcomes between patients in this group with those who had a complete pathologic response after surgical resection to address whether W&W approach has an oncologic efficacy in terms of overall survival, disease-free survival, local relapse, and distant relapse, and also whether it should be implemented in clinical practice.
Since its introduction in the early 1980s, Trans-anal Endoscopic Microsurgery (TEM) has become the standard treatment for benign rectal lesions not amenable to endoscopic excision and for low risk early rectal cancers. In 2010 Trans Anal Minimal Invasive Surgery (TAMIS), which uses a disposable platform, was introduced to simplify the technique and to increase its popularity. The aim of the present study was to compare TEM and TAMIS in terms of incidence of R1 resection, fragmentation, perioperative operative complication.
Neoadjuvant chemoradiotherapy has become the standard treatment for locally advanced rectal cancer. Watchful waiting (WW) strategy was used in a few patients with clinical complete response (cCR).
Palliative care may play a role in the management of stage IV rectal adenocarcinoma, but its use among this population is not well studied.
Previous studies have shown high rates of positive circumferential resection margin (CRM) after proctectomy in the US. We sought to explore whether widespread deployment of neoadjuvant therapy has impacted the national rate of positive CRM.
Recent reports have described the use and efficacy of several types of transanal tube (TATs) for preventing anastomotic leakage by reducing the intraluminal pressure. The goal of this study was to evaluate the safety and efficacy of a newly developed TAT for prevention of anastomotic leakage after low anterior resection (LAR) surgery for rectal cancer.