Tolerogenic Dendritic Cells: The Pearl of Immunotherapy in Organ Transplantation

In this study, we summarized the properties, ex vivo generation, metabolism, and clinical attempts of Tol-DC. Tol-DC is expected to become a substitute for IS to enable patients to achieve immune tolerance in the future.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

Acute and chronic rejection as well as the deleterious effects associated with long-term immunosuppression are leading causes of allograft failure following transplantation. The use of “regulatory” cell therapy to prevent graft-versus-host disease (GVHD) and improve solid organ transplant outcomes has been a long-standing endeavor. While numerous murine studies have documented the effects of various “regulatory” cell types in modulating the alloimmune response in favor of graft tolerance, translation to pre-clinical and clinical models has been met with mixed results.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
Conclusions: Anesthetic considerations in FT span the continuum of care. Future efforts should guide standard reporting to establish evidence-based strategies that promote quality improvement and patient safety.
Source: Plastic and Reconstructive Surgery Global Open - Category: Cosmetic Surgery Tags: Reconstructive: Special Topic Source Type: research
Abstract The BK polyomavirus was isolated in 1971; it has been a significant risk factor for both graft dysfunction and failure in renal transplant recipients. So far, no specific treatment option has been available for effective treatment or prophylaxis for BK virus infections. Although the use of heavy immunosuppression has been the main risk factor for BK virus infection, other risk factors are equally important, including elderly recipients, prior rejection episodes, male sex, human leukocyte antigen mismatching, prolonged cold ischemia time, pretransplant BK virus serostatus, and ureteral stenting. Regular fo...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
Myeloid-derived suppressor cells (MDSC) represent a heterogeneous group of myeloid regulatory cells that were originally described in cancer. Several studies in animal models point to MDSC as important players in the induction of allograft tolerance due to their immune modulatory function. Most of the published studies have been performed in animal models, and the data addressing MDSCs in human organ transplantation are scarce. We evaluated the phenotype and function of different MDSCs subsets in 38 kidney transplant recipients (KTRs) at different time points. Our data indicate that monocytic MDSCs (Mo-MDSC) increase in KT...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion Vascularized composite allotransplantation continues to advance with improving immunotherapy and outcomes in solid organ transplantation. Optimizing surgical techniques remains paramount as the field continues to grow. Refinement of the presented methods will continue as additional evidence and outcomes become available in AW-VCA. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Reconstructive Microsurgery - Category: Surgery Authors: Tags: Original Article Source Type: research
Immunotherapy, Ahead of Print.
Source: Immunotherapy - Category: Allergy & Immunology Authors: Source Type: research
In conclusion, this is the first report that demonstrates a large-scale generation of allospecific iTregs that preserve a stable phenotype and suppressor function in the presence of pro-inflammatory cytokines and pave the way for adoptive cell therapy with iTregs in transplanted patients.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Contributors : Amy J Wisdom ; Yvonne M Mowery ; David G Kirsch ; Dadong Zhang ; Xiaodi Qin ; Kouros OwzarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAbstract: Transplanted tumors in syngeneic mice treated with immune checkpoint blockade and radiotherapy demonstrate synergy and an abscopal effect. Indeed, tumors generated from sarcoma cell lines transplanted into syngeneic mice are cured by PD-1 blockade and radiotherapy, but autochthonous, primary sarcomas from the same high mutational load model are resistant to the identical treatment. Here, we generated a single cell atlas of t...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Ultraviolet (UV)-induced DNA damage, suppression of anti-tumor immune responses and promotion of cutaneous inflammation underly the skin tumor promoting activities of sunlight. Targeting the immune regulatory pathways activated by UV is proving a highly effective therapeutic strategy to treat both melanoma (Hodi et al., 2010) and keratinocyte cancers (Day et al., 2017). However, many of these first generation check-point inhibitors come with significant side effects including increased risk of autoimmune toxicities (Phan et al., 2003) and rejection of allografts in some transplant recipients at high risk of metastatic skin...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
More News: Allergy & Immunology | Bone Graft | Immunotherapy | Study | Transplants