Malignant Granular Cell Tumor of the Esophagus: A Case Report.

CONCLUSION: Esophageal MGCT requires a detailed presentation including long-term survival. Early surgical removal of intramural esophageal neoplasms with potentially malignant features is highly recommended. Radical and/or repeated esophageal resections are the only known therapies with curative potential. PMID: 33012751 [PubMed - as supplied by publisher]
Source: Annals of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Cardiovasc Surg Source Type: research

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There are several different types of gastric neoplasm, depending on the cell of origin. The most common gastric neoplasm is adenocarcinoma followed by lymphoma, gastrointestinal stromal tumours (GISTs), carcinoids and other rarer neoplasms. Gastric adenocarcinoma is one of the most common cancers worldwide, especially in the Far East. In the UK, the incidence is lower, but the poor prognosis of late stage disease means the impact on population health is significant. Most patients present with advanced disease at diagnosis.
Source: Surgery (Medicine Publishing) - Category: Surgery Authors: Tags: Oesophagus and stomach Source Type: research
Contributors : Keiichi Ohshima ; Keiichi HatakeyamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensMutually exclusive KIT and PDGFRA mutations are considered to be the earliest events in gastrointestinal stromal tumors (GISTs), but insufficient for their malignant progression. Here, we explored to identify driver genes and signaling pathways relevant to GIST progression. We investigated gene expression along with genetic profiles of 707 driver genes, including mutations, gene fusions, copy number gain or loss, for 65 clinical specimens of surgically dissected GISTs, consisting of 6 metastasis and 59 prima...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Esophageal submucosal tumors (SMTs) are tissue protuberances covered with normal mucosa, usually without clinical symptoms. In esophagus, leiomyomas and gastrointestinal stromal tumors (GISTs) are two common SMTs and originate from the muscularis propria (MP) layer. The most are benign, but 10.8% leiomyomas might turn into leiomyosarcomas. GISTs are reported to be potentially malignant, especially with the large size or irregular boundary. Submucosal tunneling endoscopic resection (STER) and endoscopic submucosal excavation (ESE) are recently introduced to remove submucosal tumors (SMTs) originating from the muscularis propria (MP) layer.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Tuesday abstract Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating β-Catenin Chunhua Liu1†, Lijing Wang1†, Qingping Jiang2†, Junyi Zhang3†, Litong Zhu1, Li Lin1, Huiping Jiang1, Dan Lin1, Yanyi Xiao1, Weiyi Fang1,3 and Suiqun Guo1* 1Department of Obstetrics and Gynecology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China 2Department of Pathology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China 3Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guang...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Our analysis supports treating GIST patients with neoadjuvant imatinib, which demonstrated favorable long-term results of combined therapy. However, careful monitoring of complications is necessary. The optimal duration of neoadjuvant imatinib use before surgical intervention is, on average, 6.1 months.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsResection of selected intramural GEJ disorders through a minimally invasive transgastric approach can be performed safely with acceptable morbidity and good long-term results. The approach allows preservation of the lower esophageal sphincter and vagus nerves, a potential advantage compared with other surgical alternatives to resection in this region.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions: STER is a safe and feasible technique for treating esophageal SMTs originating from the muscularis propria layer. PMID: 30622559 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
We report a very rare case of collision tumor composed of primary adenocarcinoma of the jejunum and gastrointestinal stromal tumor (GIST). The patient was a 63-year-old man who visited our hospital for epigastralgia and vomiting. Abdominal computed tomography revealed a mass in the upper jejunum, with gastric and duodenal dilatation. Endoscopy of the small bowel showed a circumferential tumor in the upper jejunum, which was diagnosed as primary adenocarcinoma by tissue biopsy. Thereafter, partial resection of the small bowel from the third part of the duodenum over the upper jejunum was performed. A tumor colliding with th...
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 16 November 2018Source: The American Journal of SurgeryAuthor(s): Basem Azab, Francisco Igor Macedo, Samuel H. Cass, Caroline Ripat, Sayed Razi, Omar Picado, Dido Franceschi, Alan S. Livingstone, Danny YakoubABSTRACTBackgroundEsophageal gastrointestinal stromal tumors (E-GIST) and leiomyosarcoma (E-LMS) are rare tumors. Previous studies are limited to small number of patients. We sought to study these two tumors using a large national database.MethodsThe National Cancer Data Base 2004-2014 was queried for patients with E-GIST and E-LMS. The primary outcome was overall survival (OS). Univa...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
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