Human Amniotic Fluid Stem Cells Attenuate Cholangiocyte Apoptosis in a Bile Duct Injury Model of Liver Ductal Organoids
Biliary atresia (BA) is a fibro-obliterative cholangiopathy that involves both extrahepatic and intrahepatic bile ducts in infants. Cholangiocyte apoptosis has an influence on the fibrogenesis process of bile ducts and the progression of liver fibrosis in BA. Human amniotic fluid stem cells (hAFSCs) are multipotent cells that have ability to inhibit cell apoptosis. We aimed to investigate whether hAFSCs have the potential to attenuate cholangiocyte apoptosis and injury induced fibrogenic response in our ex vivo bile duct injury model of liver ductal organoids.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Sinobol Chusilp, Carol Lee, Bo Li, Dorothy Lee, Masaya Yamoto, Niloofar Ganji, Paisarn Vejchapipat, Agostino Pierro Source Type: research
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