Peripheral vascular endothelial growth factor changes after transcranial magnetic stimulation in treatment-resistant depression

Objectives
To determine if vascular endothelial growth factor (VEGF) changes with transcranial magnetic stimulation (TMS) in treatment-resistant major depressive disorder (MDD).
Methods
Serum from a naturalistic population of 15 patients with MDD was collected at baseline and after standard TMS treatment. VEGF concentration was determined via ELISA. Inventory of Depressive Symptomatology Self Report and Patient Health Questionnaire were used as a measure of depression symptom severity, clinical response and remission. Mann–Whitney U and Kendall’s Tau Correlation were used for continuous variables.
Results
VEGF increased from pre- to post-TMS (+30.3%) in remitters whereas VEGF decreased in non-remitters (−9.87%) (P

Source: NeuroReport - October 6, 2020 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research