Association of Placenta-Derived Extracellular Vesicles with Preeclampsia and Associated Hypercoagulability: A clinical observational study.

Association of Placenta-Derived Extracellular Vesicles with Preeclampsia and Associated Hypercoagulability: A clinical observational study. BJOG. 2020 Oct 03;: Authors: Chen Y, Huang P, Han C, Li J, Liu L, Zhao Z, Gao Y, Qin Y, Xu Q, Yan Y, Wang Y, Ren J, Men J, Dong JF, Zhang J, Xue F Abstract OBJECTIVE: Preeclampsia (PE) is a pregnancy-associated condition initiated by placental factors. We have demonstrated that placental extracellular vesicles (pcEVs) cause hypertension and proteinuria in pregnant and non-pregnant mice. STUDY DESIGN: An observational study with both case-control and longitudinal designs. SETTING: A single center at the Department of Obstetrics and Gynecology, Tianjin Medical University. POPULATION: We collected blood samples and clinical information from 54 PE patients, 33 normally pregnant women with at 30-36 gestational weeks and on postpartum days 1 and 4 for the cross-sectional study, and at 22-31, 32-35, and 36-40 weeks for the longitudinal study. Non-pregnant women were also recruited. METHODS: Blood samples were analyzed using flow cytometry, coagulation tests, and ELISA. MAIN OUTCOME MEASURES: The primary outcome was plasma pcEVs and other extracellular vesicles (EVs), and their expressions of anionic phospholipids and von Willebrand factor (VWF). Secondary variables included coagulation, ADAMTS-13, and the anionic phospholipid-binding proteins. RESULTS: Plasma pcEVs progressively increased from ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research

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