Pathogenesis of inclusion body myositis

Purpose of review To review the pathogenesis of inclusion body myositis (IBM). Recent findings IBM is an autoimmune disease. Multiple arms of the immune system are activated, but a direct attack on muscle fibers by highly differentiated T cells drives muscle destruction. Summary Further understanding of the pathogenesis of IBM guides rational approaches to developing therapeutic strategies.
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: MYOSITIS AND MYOPATHIES: Edited by Andrea Doria, Anna Ghirardello and Mariele Gatto Source Type: research