Increased expression of CXCL2 in ACPA-positive rheumatoid arthritis and its role in osteoclastogenesis.

In conclusion, CXCL2 was highly expressed in ACPA+ RA than in ACPA- RA. CXCL2 promoted osteoclastogenesis and was related to bone erosion in RA, which suggest that the blockade of CXCL2 might be a novel strategy for the treatment of RA.
PMID: 33010041 [PubMed - as supplied by publisher]

Source: Clinical and Developmental Immunology - October 2, 2020 Category: Allergy & Immunology Authors: Wang X, Sun L, He N, An Z, Yu R, Li C, Li Y, Li Y, Liu X, Fang X, Zhao J Tags: Clin Exp Immunol Source Type: research