Inhaled corticosteroids as treatment for adolescent asthma: effects on adult anxiety-related outcomes in a murine model

ConclusionsThese findings suggest that steroid medications for youth with allergic asthma may not exacerbate anxiety-related symptoms, and that they  should be avoided in children/adolescents without a health condition. The results are informative to future work on the use of corticosteroid medications during childhood or adolescent development.
Source: Psychopharmacology - Category: Psychiatry Source Type: research

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Background: There is little information on the state of asthma, particularly severe asthma, in China.Objectives: To determine the characteristics of severe asthma patients in China and their stability.Methods: We recruited adults with severe asthma (n=349 non-smokers, NSA, &n=114 smokers and ex-smokers, SSA), mild/moderate asthma (MMA; n=97) and healthy controls (HS, n=100) from 33 university hospitals in 15 provinces. Severe asthma was defined by 2014 ERS/ATS guidelines.Results: NSA was mostly female (70%) but SSA exclusively (96.5%), with both groups having most obese subjects (BMI>28) (NSA: 14.6% and SSA: 17.5% v...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Introduction: Asthma exacerbations carry significant direct and indirect healthcare implications. Identifying characteristics to predict recurrent exacerbations requiring oral corticosteroids (OCS) could help patients and clinicians make personalised treatment decisions. Sputum eosinophil count though predictive is not always practical in the clinic setting.Aims: To identify characteristics associated with recurrent OCS use in biological therapy naïve patients in the WATCH cohort of difficult asthma.Methods: Univariate analysis was used to identify co-morbidities with trends for significance (P4 courses of rescue OCS in ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Introduction: Comorbidities and poor adherence are common features in patients with difficult-to-control asthma. However, the relative effect of these parameters on asthma control and exacerbations is less investigated.Aim: To examine the impact of comorbidities, poor inhaler technique and adherence on asthma control and frequent exacerbations in a representative cohort of patients with difficult-to-control asthma.Methods: All adult asthma patients (n=1034) seen in four respiratory clinics over one year were screened prospectively for asthma severity. Patients with difficult-to-control asthma according to ERS/ATS criteria ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Poor control in patients with difficult-to-treat asthma might be due to several factors, including poor adherence and undertreated asthma co-morbidities. After an assessment addressing these issues, only few patients still need targeted therapy.We aimed to evaluate the effect of a multidimensional intervention in improvement asthma control in patients with difficult asthma.Fifty patients with difficult asthma were prospectively included in this study conducted in AbderrahmenMami hospital between March 2018 and September 2018. Clinical, biological and functional characteristics were collected. Then, coexisting conditions (p...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
Chronic rhinosinusitis is a long-lasting medical condition, usually caused by infection or exposure to irritants, such as allergies, that affects one in seven American adults. Symptoms include nasal obstruction, nasal congestion, nasal drainage, loss of smell and taste, and facial pain and pressure. Some people with chronic rhinosinusitis also develop additional symptoms, such as asthma and nasal polyps, that are exacerbated by underlying allergies. A nasal polyp is a noncancerous tumor that grows from the lining of the nose or sinuses and affects the drainage system of the sinuses. While chronic rhinosinusitis is not a li...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Cold and Flu Drugs and Supplements Ear, nose, and throat Health Source Type: blogs
Gastro-oesophageal reflux disease (GORD) has long been associated with poor asthma control without an established cause-effect relationship.610 asthmatics (421 severe/88 mild-moderate) and 101 healthy controls were assessed clinically and a subset of 154 severe asthmatics underwent proteomic analysis of induced sputum using untargeted mass spectrometry, LC-IMS-MSE. Univariate and multiple logistic regression analyses (MLR) were conducted to identify proteins associated with GORD in this cohort.When compared to mild/moderate asthmatics and healthy individuals, respectively, GORD was three- and ten-fold more prevalent in sev...
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research
Conclusions: High levels of emotional distress are common in children with PSA and are associated with parental anxiety and depression. Attention to psychological morbidity in children and their families is a vital component of asthma care.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
Conclusion: Obese asthmatics appear to perceive their symptoms as more severe, have a greater prevalence of functional co-morbidities and lose a greater number of days to illness, but have lower airway inflammation as assessed by FeNO. Different mechanisms may be driving symptoms in Obese-Difficult Asthma, requiring specific assessment and management strategies.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Background: Personalised therapy for COPD patients is debated. We investigated whether the rate of FEV1 decline differs between patients with and without ICS-containing medications, stratified by blood EOS level.Methods: The UK Clinical Practice Research Datalink (primary care records) and Hospital Episode Statistics (hospital records) were used to identify COPD patients with ≥2 FEV1 measurements ≥6 months apart. Follow-up started from first FEV1 until censoring at death, leaving database or first ICS-containing prescription (if not baseline ICS-containing user). The nearest blood EOS 2 years prior to the start of fo...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Conclusion: Asthma patients entering PR are highly complex in terms of symptoms, exacerbation frequency, oral corticosteriod dependency, current smoking, high prevalence of obesity and other comorbidities. Nevertheless, the current results show that PR is a successful intervention for these patients with clinically meaningful improvements in functional capacity and quality of life.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rehabilitation and Chronic Care Source Type: research
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