Kidney Cancer: An Overview of Current Therapeutic Approaches.

Kidney Cancer: An Overview of Current Therapeutic Approaches.
Urol Clin North Am. 2020 Nov;47(4):419-431
Authors: Chowdhury N, Drake CG
Abstract
The management of metastatic renal cell carcinoma (RCC) has evolved rapidly in recent years with several immunotherapy-based combinations of strategies approved as first-line therapies. Targeted strategies, including systemic antiangiogenesis agents and immune checkpoint blockade, form the basis of a therapeutic approach. With rising rates of recurrence after first-line treatment, it is increasingly important to not only adopt a personalized treatment plan with minimal adverse events but also develop predictive biomarkers for response. This review discusses currently available first-line and second-line therapies in RCC and their pivotal data, with specific focus on ongoing clinical trials in the adjuvant setting, including those involving novel agents.
PMID: 33008493 [PubMed - as supplied by publisher]

Source: The Urologic Clinics of North America - October 4, 2020 Category: Urology & Nephrology Authors: Chowdhury N, Drake CG Tags: Urol Clin North Am Source Type: research