Application of Single-Cell Sequencing to Immunotherapy.

Application of Single-Cell Sequencing to Immunotherapy. Urol Clin North Am. 2020 Nov;47(4):475-485 Authors: Beaumont KG, Beaumont MA, Sebra R Abstract Cancer is a highly complex and heterogeneous disease and immunotherapy has shown promise as a therapeutic approach. The increased resolution afforded by single-cell analysis offers the hope of finding and characterizing previously underappreciated populations of cells that could prove useful in understanding cancer progression and treatment. Urologic and prostate cancers are inherently heterogeneous diseases, and the potential for single-cell analysis to help understand and develop immunotherapeutic approaches to treat these diseases is very exciting. In this review, we view cancer immunotherapy through a single-cell lens and discuss the state-of-the-art technologies that enable advances in this field. PMID: 33008498 [PubMed - as supplied by publisher]
Source: The Urologic Clinics of North America - Category: Urology & Nephrology Authors: Tags: Urol Clin North Am Source Type: research