The citrus flavanone naringenin prevents the development of morphine analgesic tolerance and conditioned place preference in male rats.

The citrus flavanone naringenin prevents the development of morphine analgesic tolerance and conditioned place preference in male rats. Am J Drug Alcohol Abuse. 2020 Oct 02;:1-9 Authors: Alifarsangi A, Esmaeili-Mahani S, Sheibani V, Abbasnejad M Abstract BACKGROUND: Opioids are effective analgesics in the management of chronic pain. However, their clinical use is hindered by adverse side effects such as addiction and analgesic tolerance. Naringenin is a common polyphenolic constituent of the citrus fruits and is one of the most commonly consumed flavonoids within our regular diet. However, its influences on opioid tolerance and addiction have not yet been clarified. OBJECTIVES: To examine the effect of different doses of naringenin on analgesic tolerance, conditioned place preference and neuroinflammation in morphine-exposed rats. METHODS: Analgesic tolerance was induced by the injection of 10 mg/kg morphine twice daily for 8 days in 70 male Wistar rats. To evaluate the effect of naringenin on the development of morphine tolerance, different doses (10, 25 and 50 mg/kg i.p.) were injected 15 min before morphine. The tail-flick test was used to assess nociceptive threshold. Conditioned place preference test was used to evaluate morphine-seeking behaviors. The lumbar spinal cord was assayed to determine glial fibrillary acidic protein (GFAP) and cyclooxygenase-2 (COX-2) levels by Western blotting. RESULTS: The data showed ...
Source: The American Journal of Drug and Alcohol Abuse - Category: Addiction Authors: Tags: Am J Drug Alcohol Abuse Source Type: research

Related Links:

  Cannabis, weed, marijuana, pot. It goes by several names, but we all know what it smells like. As weed becomes more mainstream, we on the Not Crazy podcast want to know: Is marijuana really an effective treatment for anxiety? Is it just a coping mechanism? Or a vice? In today’s podcast, Gabe and Jackie look at the research and weigh out the evidence. They also interview Eileen Davidson, a rheumatoid arthritis patient who regularly uses marijuana as a medicine to see what she has to say. What’s your take? Tune in for an open-minded discussion about weed. (Transcript Available Below) SUBSCRIBE &REV...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Medications Not Crazy Podcast Source Type: blogs
The future of healthcare is shaping up in front of our very eyes with advances in digital technologies, such as artificial intelligence, VR/AR, 3D-printing, robotics or nanotechnology. We have to familiarize with the latest developments in order to be able to control technology and not the other way around. The future of healthcare lies in working hand-in-hand with technology and healthcare workers have to embrace emerging technologies in order to stay relevant in the coming years. Be bold, curious and informed! Are you afraid that robots will take over the jobs of nurses, doctors and other healthcare professionals? Are y...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine 3d printing AI artificial intelligence augmented reality genetics Health Healthcare nanotechnology Personalized medicine pharma pharmacology robotics virtual reality wearables GC1 Source Type: blogs
What is the Definition of “Opioid”? The definition of opioid is as follows: Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, such as oxycodone, hydrocodone, codeine, morphine, and many others. Opioids work by interacting with the opioid receptors on nerve cells in the body and brain. By interacting with these receptors, opioids medications are able to cut off communication between the pain point on the body to the brain. This chemical interaction gives it’s users pain relief that is too great for ov...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction to Pharmaceuticals fentanyl heroin heroin addiction opiate opiate abuse opiate addiction opiates opioid opioids Source Type: blogs
This study aimed to investigate a potential correlation between NGF serum levels and brain structural differences in schizophrenia. Furthermore, a potential overlap between the results of a whole brain correlation analysis between GMV and NGF serum levels and the results of GMV reductions in schizophrenia patients were identified in a conjunction analysis.Materials and MethodsSubjectsEighteen schizophrenia patients from the Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, Aachen, Germany, and 19 gender- and age-matched healthy controls from the general population participated in ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion and Future Directions G protein bias may either be affinity/potency-dominant or efficacy-dominant (Table 1). A potential concern is that, despite using the same cellular assays, variations in agonist potency were determined by different, or even the same labs, potentially due to differences in expression levels of the receptor and signaling proteins that occurred during cell passaging. For example the reported arrestin recruitment potency for U69,593 has been reported to be as low as 67.7 nM (Spetea et al., 2017) and as high as 410 nM (Dunn et al., 2018), similarly for U50,488 potency has ranged from 36 to 1000...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we investigated the role of the small conductance calcium-activated potassium channels (SK channels) in NAc and mPFC after morphine withdrawal. Action potential (AP) firing of neurons in the NAc shell was enhanced via the downregulations of the SK channels after morphine withdrawal. Furthermore, the expression of SK2 and SK3 subunits in the NAc was significantly reduced after 3 weeks of morphine withdrawal, but was not altered in the dorsal striatum. In mPFC, the SK channel subunits were differentially expressed. To be specific, the expression of SK3 was upregulated, while the expression of SK2 was unchanged...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
What is a Benzodiazepine? Benzodiazepines are a prescription drug sedative used to treat a variety of conditions. They are classified as Schedule IV in the Controlled Substances Act. Some of the conditions that Benzodiazepine can treat include: Insomnia Anxiety Seizures Muscle tension Panic disorders When used as prescribed under the supervision of a medical professional, Benzodiazepines can be very useful in the treatment of these disorders. Many people are able to live healthy, happy lives while taking Benzodiazepines to curb the symptoms of their various conditions. However, because of the addictive nature of Benzodia...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Uncategorized benzo benzodiazepines prescription drug abuse prescription drug addiction prescription drug use prescription pills Source Type: blogs
 Former Congressman Patrick Kennedy joins our hosts to talk about mental health and addiction parity, both at the federal and state levels. He shares information about new initiatives, dontdenyme.org and parityregistry.org, designed to help consumers file appeals on their own, if they feel they’ve been wrongly denied coverage by their insurance companies. They speak candidly about the problems faced with regard to parity by those who live with mental health or addiction issues. And finally, they talk about how anyone can become an advocate. Subscribe to Our Show! And Remember to Review Us! About O...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Interview Policy and Advocacy The Psych Central Show Gabe Howard Parity Patrick Kennedy Vincent M. Wales Source Type: blogs
Conclusion Evidence of clinical benefit of most available apps is very limited. Design features that enhance usability and maximise efficacy were identified. A provisional 'first-pass' evaluation framework is proposed that can help decide which apps should be endorsed by government agencies following more detailed technical assessments and which could then be recommended with confidence by clinicians to their patients.What is known about the topic? Smartphone health apps have attracted considerable interest from patients and health managers as a means of promoting more effective self-management of chronic diseases, which l...
Source: Australian Health Review - Category: Hospital Management Authors: Tags: Aust Health Rev Source Type: research
More News: Addiction | Alcoholism | Back Pain | Brain | Chronic Pain | Diets | Flavonoids | Fruit | Morphine | Neurology | Nutrition | Pain | Pain Management | Substance Abuse