The citrus flavanone naringenin prevents the development of morphine analgesic tolerance and conditioned place preference in male rats.

CONCLUSION: Our results suggest that naringenin may have a potential anti-tolerant/anti-addiction property against chronic morphine misuse and that this preventive effect is associated with its anti-neuroinflammatory effects. PMID: 33006902 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33006902?dopt=Abstract

Source: The American Journal of Drug and Alcohol Abuse - October 1, 2020 Category: Addiction Authors: Alifarsangi A, Esmaeili-Mahani S, Sheibani V, Abbasnejad M Tags: Am J Drug Alcohol Abuse Source Type: research