Azithromycin and Glucosamine May Amplify the Type 1 Interferon Response to RNA Viruses in a Complementary Fashion.
Azithromycin and Glucosamine May Amplify the Type 1 Interferon Response to RNA Viruses in a Complementary Fashion.
Immunol Lett. 2020 Sep 28;:
Authors: DiNicolantonio JJ, Barroso-Aranda J, McCarty MF
Abstract
Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP-N-acetylglucosamine. Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may interact in a complementary fashion to aid their control by enhancing type 1 interferon induction.
PMID: 33002511 [PubMed - as supplied by publisher]
Source: Immunology Letters - Category: Allergy & Immunology Authors: DiNicolantonio JJ, Barroso-Aranda J, McCarty MF Tags: Immunol Lett Source Type: research