Phorbol ester activates human mesenchymal stem cells to inhibit B cells and ameliorate lupus symptoms in MRL.Faslpr mice

Conclusion: Taken together, our data demonstrate that phorbol esters might be good tool compounds to activate MSCs to inhibit B cells and suggest that our chemical approach might allow for improvements in the therapeutic efficacy of hMSCs in SLE.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Hong Kyung Lee, Hyung Sook Kim, Minji Pyo, Eun Jae Park, Sundong Jang, Hye Won Jun, Tae Yong Lee, Kyung Suk Kim, Sang-Cheol Bae, Youngsoo Kim, Jin Tae Hong, Jaesuk Yun, Sang-Bae Han Tags: Research Paper Source Type: research