Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma via AMPK-FOXO1-ULK1 signaling axis-mediated autophagy
Conclusion: We demonstrated that HDIs triggers FOXO1-dependent autophagy, which ultimately promotes EMT, limiting the clinical outcome of HDI-based therapies. Our study suggests that the combination of an HDI and a FOXO1 inhibitor is an effective therapeutic strategy for the treatment of HCC.
Source: Theranostics - Category: Molecular Biology Authors: Qiang Xiao, Hao Liu, Hong-Sheng Wang, Meng-Ting Cao, Xiao-Jun Meng, Ya-Li Xiang, Ya-Qin Zhang, Feng Shu, Qiu-Gui Zhang, Hong Shan, Guan-Min Jiang Tags: Research Paper Source Type: research
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