PML-RAR α interaction with TRIB3 impedes PPAR γ /RXR function and triggers dyslipidemia in acute promyelocytic leukemia

Conclusion: Our work reveals the critical role of the PML-RARα/PPARγ/TRIB3 axis in the development of dyslipidemia in APL patients, potentially conferring a rationale for combining ATRA/arsenic with the PPAR activator for APL treatment.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Ke Li, Feng Wang, Zhao-Na Yang, Bing Cui, Ping-Ping Li, Zhen-Yu Li, Zhuo-Wei Hu, Hong-Hu Zhu Tags: Research Paper Source Type: research