HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma

Conclusions: Our findings illustrate a crucial role for HRG in suppressing HCC via inclining TNFR1 to a pro-apoptotic cellular phenotype. Restoring HRG expression in HCC tissues might be a promising pharmacological approach to blocking tumor progression by shifting cellular fate from cell survival to apoptosis.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Xuejing Zou, Dongyan Zhang, Yang Song, Shanshan Liu, Qian Long, Liheng Yao, Wenwen Li, Zhijiao Duan, Dehua Wu, Li Liu Tags: Research Paper Source Type: research