M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation

Conclusions: The findings of this study emphasize the prominent role of M2Es during VSMC dedifferentiation and vascular tissue repair via activation of the c-Jun/AP-1 signaling pathway, which has a profound impact on the therapeutic strategies of coronary stenting techniques.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Wenhua Yan, Tianhan Li, Tieying Yin, Zhengjun Hou, Kai Qu, Nan Wang, Colm Durkan, Lingqing Dong, Juhui Qiu, Hans Gregersen, Guixue Wang Tags: Research Paper Source Type: research