Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus

Conclusions: circPPM1F is a novel positive regulator of M1 macrophage activation through the circPPM1F-HuR-PPM1F-NF-κB axis. Overexpression of circPPM1F could promote pancreatic islet injury by enhancing M1 macrophage activation and circPPM1F may serve as a novel potential therapeutic target for T1DM in children.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Caiyan Zhang, Xiao Han, Lan Yang, Jinrong Fu, Chengjun Sun, Saihua Huang, Wenfeng Xiao, Yajing Gao, Qiuyan Liang, Xiang Wang, Feihong Luo, Wei Lu, Yufeng Zhou Tags: Research Paper Source Type: research