Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma

Conclusion: DDX5 is a negative regulator of Wnt signaling and hepatocyte reprogramming in HCCs. Restoration of DDX5 levels by miR17~92 / miR106b~25 antagomirs in HBV-infected patients can be explored as both antitumor and antiviral strategy.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Saravana Kumar Kailasam Mani, Bingyu Yan, Zhibin Cui, Jiazeng Sun, Sagar Utturkar, Adrien Foca, Nadim Fares, David Durantel, Nadia Lanman, Philippe Merle, Majid Kazemian, Ourania Andrisani Tags: Research Paper Source Type: research