Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis

Conclusion: Statin induces miR-495 to suppress Sirt6 expression, which leads to enhancement of FoxO1-mediated hepatic gluconeogenesis. Thus, Sirt6 activation may offer a promising strategy for preventing statin-induced hyperglycemia.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Min Yan Shi, In Hyuk Bang, Chang Yeob Han, Dae Ho Lee, Byung-Hyun Park, Eun Ju Bae Tags: Research Paper Source Type: research