ROS production and mitochondrial dysfunction driven by PU.1-regulated NOX4-p22phox activation in A β -induced retinal pigment epithelial cell injury

Conclusion: Our study suggests that PU.1 is a novel therapeutic target for AMD, and the regulation of PU.1 expression represents a potentially novel approach against excessive oxidative stress in Aβ-driven RPE injury.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Junran Sun, Jieqiong Chen, Tong Li, Peirong Huang, Jie Li, Mengxi Shen, Min Gao, Yang Sun, Jian Liang, Xiaomeng Li, Yimin Wang, Yushu Xiao, Xiang Shi, Yifan Hu, Jingyang Feng, Huixun Jia, Te Liu, Xiaodong Sun Tags: Research Paper Source Type: research