Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation

Conclusion: Natural compound emodin suppresses EMT and CSC formation of breast cancer cells by blocking TGF-β1-mediated crosstalk between TAMs and breast cancer cells. Our study provides evidence suggesting that emodin harbors the potential for clinical development as a new effective and safe agent to halt metastatic recurrence of breast cancer.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qing Liu, Johnie Hodge, Junfeng Wang, Yuzhen Wang, Lianming Wang, Udai P. Singh, Yong Li, Yongzhong Yao, Dawei Wang, Walden Ai, Prakash Nagarkatti, Hexin Chen, Peisheng Xu, E. Angela Murphy, Daping Fan Tags: Research Paper Source Type: research