Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells

Conclusions: These results demonstrate that SIRT4 exerts its tumor-suppressive activity via modulating SIRT1 expression in breast cancer and provide a novel cross-talk between mitochondrial and nuclear sirtuins.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Lutao Du, Xiaoyan Liu, Yidan Ren, Juan Li, Peilong Li, Qinlian Jiao, Peng Meng, Fang Wang, Yuli Wang, Yun-shan Wang, Chuanxin Wang Tags: Research Paper Source Type: research