Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines

Conclusions: We can conclude that MAD2 is important for GCSCs stemness and its downregulation in MKN45CSCs plays a central role in GC tumorigenesis, likely through CXCR4-SNAI2-MMP1. Thus, its potential use in the clinical setting should be studied as its functions appear to extend beyond mitosis.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Natalia Pajuelo-Lozano, Sonia Alcal á , Bruno Sainz, Rosario Perona, Isabel Sanchez-Perez Tags: Research Paper Source Type: research