Suppression of antigen presentation by IL-10.

Suppression of antigen presentation by IL-10.
Curr Opin Immunol. 2015 Jan 15;34C:22-27
Authors: Mittal SK, Roche PA
Abstract
Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFNγ-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.
PMID: 25597442 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - January 15, 2015 Category: Allergy & Immunology Authors: Mittal SK, Roche PA Tags: Curr Opin Immunol Source Type: research