A multi-center, prospective study on the progression rate of asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on magnetic resonance imaging to idiopathic normal pressure hydrocephalus
Introduction: Our previous community-based study demonstrated that some individuals with AVIM [asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus (iNPH) on magnetic resonance imaging (MRI)] progressed to iNPH in several years. In this hospital-based study, we investigated the progression rate from AVIM to iNPH and its possible predictors.Methods: We conducted a prospective study of participants with AVIM from several medical institutions/hospitals in Japan. AVIM is defined as “asymptomatic ventriculomegaly with features of iNPH on MRI”; in the present study, asymptomatic was defined as “0 (no symptoms) or 1 (presence of only subjective, but not objective, symptoms) on the iNPH Grading Scale (iNPH-GS).” We also measured possible predicting factors for AVIM-to-iNPH progression, including age, sex, body weight, blood pressure, diabetes mellitus, dyslipidemia, history of mental disease/head injury/sinusitis/smoking/alcohol-intake, Evans index, and the presence of DESH (disproportionately enlarged subarachnoid-space hydrocephalus) findings on brain MRI, and anal yzed these potential predictive values.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Luna Kimihira, Chifumi Iseki, Yoshimi Takahashi, Hidenori Sato, Hajime Kato, Hiroaki Kazui, Nagato Kuriyama, Madoka Nakajima, Masakazu Miyajima, Katsuhiro Endo, Yoshio Kobayashi, Takashi Saegusa, Yasuaki Takeda, Shunsuke Sato, Yusuke Tomogane, Toru Baba, Tags: Clinical short communication Source Type: research
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