Is Opioid Use Safe in Women Trying to Conceive?

Conclusions: Our results are consistent with the hypothesis that opioid exposure while trying to conceive may be harmful, even among healthy, non-opioid-dependent women. Possible risks to fecundability and pregnancy viability are relevant to patients and providers when evaluating pain management approaches.
Source: Epidemiology - Category: Epidemiology Tags: Pharmacoepidemiology Source Type: research

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Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part BAuthor(s): Jinsoo Lee, Seong-Jin Choi, Ji-Seong Jeong, Sang Yun Kim, Sang-Hyub Lee, Mi Jin Yang, Seung-Jin Lee, Young-Jun Shin, Kyuhong Lee, Eun Ju Jeong, Sang-Yoon Nam, Wook-Joon Yu
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
We describe the most highly recommended generic and disease-specific PRO tools in SCD and discuss the challenges of incorporating them in clinical practice. EXPERT OPINION: PRO measures are essential to incorporate into SCD clinical trials either as primary or secondary outcomes. The use of PRO measures in SCD facilitates a patient-centered approach, which is likely to lead to improved outcomes. Significant challenges remain in adapting PRO tools to routine clinical use and in developing countries. PMID: 33034214 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Currently in fellowship doing bread/butter procedures (MBB, epidurals, PNB, few SCS/PNS trials, etc.) and just interviewed at a private practice spot where they do a lot of procedures that I will have not done any training in prior to graduating (e.g. IT pump, SI fusion, Vertiflex, Kypho, MILD, Discectomy, lots of SCS/PNS trials etc) and significant amount of "OR pain procedures" at a very busy practice seeing 30-40 pts/day - how many of you are commonly performing these procedures and are... private practice concern
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelera...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
When I had six years sober, my husband and I decided to get pregnant. I quit the birth control pill and entered the darkest depression of my life. I wasn’t surprised when the test results came back. After three chemical pregnancies and one miscarriage, it was clear that I was having trouble getting pregnant. But what I didn’t expect was that my fertility troubles might be related to my past struggles with addiction. And what was that common ground? A lack of progesterone. For years, I had struggled with depression. Though I never charted the highs and lows of my mental health to determine whether it was hormon...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction Alcoholism Anxiety and Panic Depression Disorders Health-related Personal Publishers Recovery Substance Abuse The Fix Women's Issues Birth Control Pills Dopamine Drug Use Estrogen Hormones Kristen McGuiness Pr Source Type: blogs
By Christopher Welsh, MD Women have some unique challenges when it comes to alcohol, tobacco and drug use and misuse. These differences are based on both biology and culturally defined expectations of women. Hormonal changes, the menstrual cycle, fertility issues, pregnancy, breastfeeding and menopause can all impact a woman’s use of substances. Women often use smaller amounts of a substance for shorter amounts of time before developing a problem. They also may have greater physical problems from their substance misuse. Alcohol, tobacco and drug use during pregnancy can present significant problems for both the ...
Source: Life in a Medical Center - Category: Universities & Medical Training Authors: Tags: Health Tips Source Type: blogs
The post Kathryn’s hints for a healthy hysterectomy appeared first on Hysterectomy Association. In January I had a total hysterectomy and bilateral salpingo-oophorectomy. I am 48 years old. Since the age of 14, I’ve had terrible periods; very very heavy, painful, long and with debilitating PMS symptoms. I was put on the pill at 14 and have tried every medical and holistic intervention since. These are my hints and tips for having a healthy hysterectomy. History 17 years ago, after a laparoscopy, I was diagnosed with moderate to severe endometriosis. I tried accupuncture, kineaseology, homeoepathy. I t...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Your Stories endometriosis hysterectomy hospital bag Source Type: news
The post Kathryn’s hints for a healthy hysterectomy appeared first on Hysterectomy Association. In January I had a total hysterectomy and bilateral salpingo-oophorectomy. I am 48 years old. Since the age of 14, I’ve had terrible periods; very very heavy, painful, long and with debilitating PMS symptoms. I was put on the pill at 14 and have tried every medical and holistic intervention since. These are my hints and tips for having a healthy hysterectomy. History 17 years ago, after a laparoscopy, I was diagnosed with moderate to severe endometriosis. I tried accupuncture, kineaseology, homeoepathy. I t...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Your Stories endometriosis hysterectomy hospital bag Source Type: news
ConclusionThis observational study reviewed the reliability of different measurements taken at a transvaginal ultrasound scan to diagnose miscarriage during early pregnancy. The recommended cut-off values for gestational sac diameter and embryo crown-to-rump length were changed in 2011 based on a number of reports, with mixed findings suggesting previous ones may have been unreliable. This study looked at the performance of currently used cut-off values, and found that the current cut-offs used to diagnose miscarriage are reliable. No healthy, continuing pregnancies would be wrongly diagnosed as miscarriage using thes...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Pregnancy/child Source Type: news
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