Newborn metabolic vulnerability profile identifies preterm infants at risk for mortality and morbidity.

CONCLUSIONS: Metabolites measured as part of routine newborn screening can be used to create a metabolic vulnerability profile. These findings lay the foundation for targeted clinical monitoring and further investigation of biological pathways that may increase the risk of neonatal death or major complications in infants born preterm. IMPACT: We built a newborn metabolic vulnerability profile that could identify preterm infants at risk for major morbidity and mortality.Identifying high-risk infants by this method is novel to the field and outperforms models currently in use that rely primarily on infant characteristics.Utilizing the newborn metabolic vulnerability profile for precision clinical monitoring and targeted investigation of etiologic pathways could lead to reductions in the incidence and severity of major morbidities associated with preterm birth.Fig. 1REFERENCE FOR RACE/ETHNICITY IS WHITE AND THE REFERENCE FOR EDUCATION IS >12 YEARS.: For continuous variables, risk/protective effect corresponds to increasing amounts of the variable. MM any mortality or morbidity, NM neonatal mortality, 1yM 1-year mortality, RDS respiratory distress syndrome, PDA patent ductus arteriosus, ROP retinopathy of prematurity, IVH intraventricular hemorrhage, BPD bronchopulmonary dysplasia, NEC necrotizing enterocolitis, PVL periventricular leukomalacia, BW birth weight, GA gestational age, Edu education, HS high school, GALT galactose-1-phosphate uridyl transferase, TSH thyroi...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research