NK cell markers predict the efficacy of IV immunoglobulins in CIDP

Conclusions The correlation between the altered NK cell population and treatment efficiency suggests a crucial role for NK cells in the still speculative mode of action of IVIg treatment. Analyzing NK cell subsets after 24 hours of treatment initiation appeared as a predictive marker for IVIg responsiveness. Further studies are warranted investigating the potential of NK cell status as a routine parameter in patients with CIDP before IVIg therapy. Classification of evidence This study provides Class I evidence that NK cell markers predict clinical response to IVIg in patients with CIDP.

http://nn.neurology.org/cgi/content/short/7/6/e884?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - October 1, 2020 Category: Neurology Authors: Mausberg, A. K., Heininger, M. K., Meyer Zu Horste, G., Cordes, S., Fleischer, M., Szepanowski, F., Kleinschnitz, C., Hartung, H.-P., Kieseier, B. C., Stettner, M. Tags: Autoimmune diseases, Chronic inflammatory demyelinating polyneuropathy Article Source Type: research