Acute Graft-versus-Host-Disease other than typical targets: between myths and facts

Acute Graft-versus-Host-Disease (aGVHD) remains a major contributor to transplantation related deaths and the most significant barrier to the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT)1,2. Despite prophylactic treatments with immunosuppressive agents, approximately 30-50% of transplantation recipients develop aGVHD targeting the well-recognized organs represented by skin, liver and gastrointestinal tract (GI). Identification of these target organs resulted in the classification of aGVHD proposed by Glucksberg3, subsequently modified by Przepiorka4 and the Mount Sinai aGVHD  (MAGIC) International Consortium5.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research