The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association With Roseola

Roseola infantum is a clinical syndrome characterized by high fever followed by the emergence of a rash. Case reports have documented an association between bulging fontanelles and roseola. We propose a novel mechanism for the development of intracranial hypertension caused by human herpesvirus 6–induced cytokine elevation leading to increased cerebrospinal fluid production.
Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: Illustrative Cases Source Type: research