CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice

ConclusionCXCR1/2 antagonist Ladarixin offers a new strategy for therapeutic treatment of acute and chronic neutrophilic airway inflammation, even in the context of corticosteroid-insensitivity.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Pellino-1 is an E3 ubiquitin ligase known to regulate virally-induced inflammation. We wished to determine the role of Pellino-1 in the host response to respiratory viruses in health and disease. Pellino-1 expression was examined in bronchial sections from patients with GOLD stage two COPD and healthy controls. Primary bronchial epithelial cells (PBECs) in which Pellino-1 expression had been knocked down were extracellularly challenged with the TLR3 agonist poly(I:C). C57...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
CONCLUSION: Scientific information regarding the COVID-19 pandemic is constantly evolving, and limited or contradictory information can lead to confusion for both patients and clinicians. It is recommended that prior to prescribing non-steroidal anti-inflammatory drugs and steroids for the treatment of headache, clinicians have open discussions with their patients about the potential risks and benefits of using these medications during the COVID-19 pandemic. This manuscript summarizes the currently available evidence and understanding about these risks and benefits to help clinicians navigate such discussions. PMID: 3...
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
ntilde;ez Margüello To determine the prevalence of influenza vaccination in chronic obstructive pulmonary disease (COPD) patients and its effect on COPD exacerbations, we conducted a retrospective population-based cohort study analyzing real-life data. We included all registered COPD patients ≥40 years old using respiratory medication during the study period (2012–2013). Influenza vaccination during the 2012/2013 campaign was the parameter studied. Moderate and severe exacerbations during 2013 were the dependent outcome variables. Logistic regression adjusting for age, gender, concomitant asthma d...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This rapid review has established that targeted interventions for influenza, COPD, CHF, diabetes, UTI and cellulitis should be identified to support increased management in primary care settings. This could result in keeping people well and reducing preventable hospital admissions where possible. We suggest that a series of rapid reviews are now conducted to identify those existing, effective interventions for COPD, CHF, diabetes and asthma that could be adapted and implemented rapidly, for primary care.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
by Kueiyu Joshua Lin, Evan Dvorin, Aaron S. Kesselheim BackgroundEvidence and guidelines do not support use of systemic steroids for acute respiratory tract infections (ARTIs), but such practice appears common. We aim to quantify such use and determine its predictors. Methods and findingsWe conducted a cohort study based on a large United States national commercial claims database, the IBM MarketScan, to identify patients aged 18 –64 years with an ARTI diagnosis (acute bronchitis, sinusitis, pharyngitis, otitis media, allergic rhinitis, influenza, pneumonia, and unspecified upper respiratory infections) recorded in a...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Abstract INTRODUCTION: Influenza vaccination is the most effective way to prevent influenza. Few studies on its rate were reported throughout China and for populations with chronic diseases. An estimation of the rates in China was accomplished. METHODS: All data were from a national cross-sectional survey of a sample representing the population aged 40 years or older in mainland China in 2014-15. A total of 74,484 individuals with complete self-reported influenza vaccination status were analyzed in 2018-19. RESULTS: The overall influenza vaccination rate was 2.4% (95% CI 1.4-3.3) with 1.7% (95% CI 1...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Chronic obstructive pulmonary disease (COPD) and asthma remain prevalent human lung diseases. Variability in both epithelial and inflammatory components resulting in pathology heterogeneity complicate the development of treatments for these diseases. Early childhood infection with parainfluenza virus or respiratory syncytial virus strongly associates with the development of asthma and COPD later in life and exacerbations of these diseases correlate with the presence of viral RNA in the lung. Well-characterized animal models of post-viral chronic lung diseases are necessary to study the underlying mechanisms of viral-relate...
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Short Communication Source Type: research
In this study, we cross-analyzed chronic lung disease caused by infection with Sendai virus (SeV) or influenza A virus in mice. Differences wee observed in both lesion composition and inflammatory profiles between SeV- and influenza A virus-induced long-term lung disease. In addition, a primary SeV infection led to worsened pathology upon secondary heterologous viral challenge while the reversed infection scheme protected from disease in response to a secondary viral challenge more than a month after the primary infection. These data demonstrate the differential impact of primary viral infections in the susceptibility to d...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
Conclusion: Influenza with CLD is associated with longer length of stay in under 50’s compared to non-CLD. Readmission and mortality were higher in CLD patients.Table 1.AgeNo of patientsPts with CLDsMean Hospital stay (Days)Pts without CLDsMean Hospital Stay(Days)18-30417(17%)11.234(83%)1.231-505818(31%)5.240(69%)2.651-6511143(39%)8.168(61%)7.566-7513956(40%)9.683(60%)11.576-8516352(32%)14111(68%)15.586-9915642(27%)19.5114(73%)20.2
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
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