Increasing levels of von Willebrand Factor and factor VIII with age in patients affected by von Willebrand disease.

CONCLUSIONS: A differential increase of VWF and FVIII:C with age was shown among in different ages and types of VWD. PMID: 32998182 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research

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CONCLUSIONS: Our findings highlight the utility of quantitative imaging approaches in assessing platelet granule content, which may help to better understand VWF storage in α-granules and to gain new insights in the etiology of VWD.PMID:34532631 | PMC:PMC8440947 | DOI:10.1002/rth2.12595
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
CONCLUSIONS: Severe COVID-19 in patients undergoing hemodialysis is associated with both acute and sustained activation of the endothelium, leading to alteration of the VWF/ADAMTS-13 axis. Lower VWF sialic acid content represents altered VWF processing and further confirms the disturbance caused to the endothelium in COVID-19.PMID:34532629 | PMC:PMC8435526 | DOI:10.1002/rth2.12582
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
CONCLUSIONS: Desialylation of O-glycans around A1 increases its activity by destabilizing the AIM.PMID:34529349 | DOI:10.1111/jth.15528
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
Conclusions: Post-LAAC anticoagulation with dabigatran may increase the risk of DRT by enhancing platelet reactivity. In light of this potential increased risk in DRT, the authors recommend against using dabigatran for post-procedural anticoagulation in patients who have undergone LAAC.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Chem Biol Interact. 2021 Sep 10;348:109657. doi: 10.1016/j.cbi.2021.109657. Online ahead of print.ABSTRACTCOVID-19 is an ongoing public health emergency that has affected millions of people worldwide and is still a threat to many more. One of the pathophysiological features of COVID-19 is associated with the activation of vascular endothelial cells (ECs) leading to the disruption of vascular integrity, coagulation and inflammation. An interlink mechanism between coagulation and inflammatory pathways has been reported in COVID-19. Multiple components are involved in these pathological pathways. Out of all, Von Willebrand Fa...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Source Type: research
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the current coronavirus disease (COVID-19) pandemic [1]. Over recent months, a plethora of novel research articles has been published, dealing with multiple aspects and manifestations of the disease. Increasing evidence points to a central role of endothelial cells in SARS-CoV-2 infection [2–5]. Early studies have already indicated increased expression of vascular and inflammatory factors (such as vascular cell adhesion molecule (VCAM)-1, interleukin (IL)-8 or monocyte-chemoattractant protein (MCP)-1) in COVID-19 lung tissue [2]. Such markers of ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
J Thromb Haemost. 2021 Sep;19(9):2122-2124. doi: 10.1111/jth.15405.NO ABSTRACTPMID:34435430 | DOI:10.1111/jth.15405
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
J Thromb Haemost. 2021 Aug 19. doi: 10.1111/jth.15502. Online ahead of print.ABSTRACTBACKGROUND: Endothelial activation has been proposed as a potential mechanism for the increased risk of venous thrombo-embolism (VTE) in human immunodeficiency virus (HIV) infected pregnancy.OBJECTIVES: To assess the state of endothelial activation in HIV infected pregnancy by measuring the von Willebrand factor (VWF) propeptide to antigen ratio, as an index of acute endothelial activation.METHODS: VWF antigen and VWF propeptide were measured in HIV negative participants (n=85), HIV infected virologically suppressed participants (n=89) and...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
Ann Biomed Eng. 2021 Aug 16. doi: 10.1007/s10439-021-02845-5. Online ahead of print.ABSTRACTvon Willebrand Factor is a mechano-sensitive protein circulating in blood that mediates platelet adhesion to subendothelial collagen and platelet aggregation at high shear rates. Its hemostatic function and thrombogenic effect, as well as susceptibility to enzymatic cleavage, are regulated by a conformational change from a collapsed globular state to a stretched state. Therefore, it is essential to account for the conformation of the vWF multimers when modeling vWF-mediated thrombosis or vWF degradation. We introduce a continuum mod...
Source: Annals of Biomedical Engineering - Category: Biomedical Engineering Authors: Source Type: research
This article takes the reader to every area of the diagnostic hemostasis laboratory to appreciate the myriad applications of snake venoms available in diagnostic practice. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Tags: Review Article Source Type: research
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