IGF-1R/ β-catenin signaling axis is implicated in streptozotocin exacerbating bone impairment in ovariectomized rats.

CONCLUSION: OVX plus STZ induced more serious bone impairment than OVX alone, which involves the IGF-1R/β-catenin signaling axis in the pathogenesis. This may provide a potential target for treatment of postmenopausal diabetic osteoporosis.
PMID: 33000666 [PubMed - as supplied by publisher]

Source: Climacteric - September 30, 2020 Category: Geriatrics Authors: Zhang Z, Ren H, Shen G, Zhao W, Shang Q, Yu X, Lu Y, Yu P, Zhang Y, Tang J, Liang D, Jiang X Tags: Climacteric Source Type: research