Role of Forkhead transcription factors of the O class (FoxO) in development and progression of Alzheimer's disease.

Role of Forkhead transcription factors of the O class (FoxO) in development and progression of Alzheimer's disease. CNS Neurol Disord Drug Targets. 2020 Sep 30;: Authors: Goswami S, Goyal RK, Mumtaz SM, Tonk RK, Gupta R, Pottoo FH Abstract In the central nervous system (CNS), a specific loss of focal neurons leads to mental and neurological disorders like dementia, Alzheimer's disease (AD), Huntington's disease, Parkinson's disease, etc. AD is a neurological degenerative disorder, which isprogressive and irreversible in nature and is the widely recognized reason for dementia in the geriatric populace. It affects 10% of people above the age of 65andis the fourth driving reason for death in the United States.Numerous evidence suggests that the neuronal compartment is not the only genesis of AD, but transcription factorsalso hold significant importance in the occurrence and advancement of the disease.It is the need of the time to find the novel molecular targets and new techniques for treating or slowing down the progression of neurological disorders, especially AD. In this article, we summarised a conceivable association between transcriptional factors and their defensive measures against neurodegeneration and AD. The mammalian forkhead transcription factors of the class O (FoxO) illustrateone of the potential objectives for the development of new methodologies against AD and other neurocognitive disorders. The presence of FoxO is easi...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research