Spontaneous Atherosclerosis in Aged LCAT-Deficient Hamsters With Enhanced Oxidative Stress.

CONCLUSIONS: Our study demonstrates the development of spontaneous atherosclerotic lesions in aged male and female LCAT-/- hamsters with higher plasma oxidative lipid levels independent of plasma total cholesterol levels, further confirming the antiatherosclerotic role of LCAT.
PMID: 32998519 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2020 Category: Cardiology Authors: Guo M, Liu Z, Xu Y, Ma P, Huang W, Gao M, Wang Y, Liu G, Xian X Tags: Arterioscler Thromb Vasc Biol Source Type: research