Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.

CONCLUSIONS: Certain survivors are more susceptible to cisplatin-induced neurotoxicity, markedly increasing likelihood of developing numerous neuro-otological symptoms that affect quality of life. Genome-wide analysis identified genetic variation in FAM20C as a potentially important risk factor.
PMID: 32998964 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - September 29, 2020 Category: Cancer & Oncology Authors: Trendowski MR, Wheeler HE, El Charif O, Feldman DR, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Einhorn LH, Travis LB, Dolan ME Tags: Clin Cancer Res Source Type: research