COX-Prostaglandin Pathway Inhibition May Augment the Effects of Immunotherapy in Breast Cancer

Prostaglandins, generated by action of cyclooxygenase (COX) isoenzymes, are important mediators of inflammation. The COX-prostaglandin pathway also regulates tumorigenesis, allowing cancer cells to evade apoptosis and invade tissues. Nonetheless, the role of the COX-prostaglandin pathway in breast cancer progression and response to immunotherapy remains elusive. We hypothesized that dysregulation of prostaglandin-mediated signaling in the tumor microenvironment might suppress tumor-infiltrating lymphocytes, and that inhibiting prostaglandin expression might synergize with immunotherapeutic approaches.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Breast Source Type: research