Radiation Enhances the Efficacy of B7-H3 Chimeric Antigen Receptor (CAR) T-Cell Based Immunotherapy for Triple Negative Breast Cancer (TNBC)

The need for an effective therapy for triple negative breast cancer (TNBC) prompted us to develop a novel combinatorial immunotherapy using chimeric antigen receptor (CAR) T-cells targeting the tumor-antigen B7-H3 (B7-H3 CAR T-cells) as the effector mechanism. B7-H3 was selected because it is highly expressed on differentiated and cancer-initiating TNBC cells, up-regulated on tumor-associated fibroblasts and stroma, and has limited distribution in normal tissues. B7-H3 CAR T-cells were combined with radiation to enhance their anti-tumor activity, since radiation modulates the expression of molecules relevant to CAR T-cell anti-tumor activity.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Breast Source Type: research