Outcomes of Children With Cystic Fibrosis Admitted to PICUs*

Conclusions: The mortality rate during PICU admissions for patients with cystic fibrosis is lower than has been reported in prior studies, both in the overall cohort and in the subset requiring invasive mechanical ventilation. These data provide updated insight into the prognosis for cystic fibrosis patients requiring critical care.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

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Approximately 1 in 4 women with menorrhagia and dysmenorrhea have clinical evidence of adenomyosis. For those who have completed childbearing, hysterectomy provides definitive symptom management. Several medical options, including combined oral contraceptives, GnRH agonist/antagonist, and antiandrogens, can be used if future fertility is desired. The levonorgestrel-releasing intrauterine device (LNG-IUD) is a highly effective alternative, with evidence suggesting reductions in pain, bleeding, and even uterine volumes among women with adenomyosis (1).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
In this issue of JMIG, we highlight a pilot study of primary hysteroscopic management of early miscarriage. Historically, patients have been offered a dilation and curettage (D&C) as the only surgical treatment option for miscarriage. Typically done without ultrasound guidance, D&Cs may be associated with complications including bleeding, infection, and perforation.1 –3 Importantly, D&Cs can disrupt the basalis layer of the endometrium leading to increased risk of intrauterine adhesions and subsequent hypofertility.1 Risk of intrauterine adhesions after miscarriage have been reported as high as 40% and may be increas...
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: EDITORIAL Source Type: research
Approximately 1 in 5 patients undergo noncardiac surgery within the first year after a drug-eluting stent (DES) implantation.1 –3 For these patients, it is recommended that a multidisciplinary team, including cardiologists and surgeons, evaluates the indication for and timing of the surgery and the consequences of interrupting dual antiplatelet therapy (DAPT). Such consequences include an increased risk of thrombotic even ts such as stent thrombosis and risk of bleeding associated with surgery.4,5 Based on 2 recent cohort studies,3,6 the 2018 European Society of Cardiology DAPT consensus document suggested that when ...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Cristiane Yumi Koga-Ito The increasing incidence of antifungal resistance represents a great challenge in the medical area and, for this reason, new therapeutic alternatives for the treatment of fungal infections are urgently required. Cold atmospheric plasma (CAP) has been proposed as a promising alternative technique for the treatment of superficial candidiasis, with inhibitory effect both in vitro and in vivo. However, little is known on the association of CAP with conventional antifungals. The aim of this study was to evaluate the effects of the association between CAP and conventional polyene antifungals on Candid...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Dear Editor,
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Letter to the Editor Source Type: research
Acute variceal bleeding is a complication of portal hypertension, usually due to cirrhosis, with high morbidity and mortality. There are 3 scenarios for endoscopic treatment of esophageal varices: prevention of first variceal bleed, treatment of active variceal bleed, and prevention of rebleeding. Patients with cirrhosis should be screened for esophageal varices. Recommended endoscopic therapy for acute variceal bleeding is endoscopic variceal banding. Although banding is the first-choice treatment, sclerotherapy may have a role. Treatment with Sengstaken-Blakemore tube or self-expanding covered metallic esophageal stent c...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
CONCLUSIONS: Given the very low quality of the evidence identified in this updated Cochrane Review we are uncertain whether any of the assessed pharmaceutical interventions reduce ulcer size or result in leg ulcer closure in treated participants compared to controls. However, this intervention was assessed as having a high risk of bias due to inadequacies in the single trial report. Other included studies were also assessed as having an unclear or high risk of bias. The harm profile of the all interventions remains inconclusive.PMID:34559425 | DOI:10.1002/14651858.CD008394.pub4
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: No RCTs or CCTs compared either surgery or endovascular therapy with control. Thus, there is no available evidence to support their use for the treatment of extracranial cervical artery dissection in addition to antithrombotic therapy in people who continue to have neurological symptoms when treated with antithrombotic therapy alone.PMID:34559418 | DOI:10.1002/14651858.CD013118.pub2
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research
J Thromb Haemost. 2021 Oct;19(10):2629. doi: 10.1111/jth.15443.NO ABSTRACTPMID:34558779 | DOI:10.1111/jth.15443
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
Circ J. 2021 Sep 23. doi: 10.1253/circj.CJ-21-0751. Online ahead of print.ABSTRACTOptimal antiplatelet therapy after percutaneous coronary intervention (PCI) has been changed in parallel with the improvements of coronary stent and antiplatelet therapy. Over the past 25 years, dual antiplatelet therapy (DAPT) with aspirin plus P2Y12inhibitor has been the standard of care used after coronary stent implantation. First-generation drug-eluting stent (DES) appeared to increase the risk of late stent thrombosis, and duration of DAPT was prolonged to 12 months. DAPT duration up to 12 months was the dominant strategy after DES impl...
Source: Circulation Journal - Category: Cardiology Authors: Source Type: research
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