Risk Factors for Malignant Transformation of Squamous Intraepithelial Lesions

Squamous intraepithelial lesions (SIL) are persistent white and white-red lesions that may represent precursor lesions for invasive squamous cell carcinoma (SCC). SILs encompass epithelial hyperplasia/hyperkeratosis, dysplasia, and carcinoma in situ. Specific indicators within SILs would be helpful for risk determination and treatment decisions. The purpose of this study was to determine the risk of SIL transformation to SCC using clinical appearance, histology, and immunohistochemical staining of biomarkers.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research