Risk Factors for Malignant Transformation of Squamous Intraepithelial Lesions
Squamous intraepithelial lesions (SIL) are persistent white and white-red lesions that may represent precursor lesions for invasive squamous cell carcinoma (SCC). SILs encompass epithelial hyperplasia/hyperkeratosis, dysplasia, and carcinoma in situ. Specific indicators within SILs would be helpful for risk determination and treatment decisions. The purpose of this study was to determine the risk of SIL transformation to SCC using clinical appearance, histology, and immunohistochemical staining of biomarkers.
This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.METHODS: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.RESULTS: The results of IHC revealed the expression patterns of...