The Effect of Proton Pump Inhibitors on Long-Term Implant Success

Proton pump inhibitors (PPIs) are often prescribed to patients for the prevention and treatment of acid-related conditions, such as gastroesophageal reflex disease, peptic ulcers, dyspepsia, and Helicobacter pylori infections. As their name indicates, PPIs act by preventing proton transport into the stomach lumen by covalently binding to and reversibly blocking the H+-K+-ATPase on gastric parietal cells.1 This mechanism can be effective in treatment of ulcers and other acid-related conditions. Interestingly, PPIs are thought to be associated with an increased risk of osteoporosis or bone fracture.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research