ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue

Carrasco et  al. show that the two neuron-specific RNA-binding proteins ELAV and FNE define the unique identity of neuronal messenger RNAs. When not repressed by ELAV, FNE undergoes a functional switch and rescues neuronal 3′ end processing and splicing in a process termed exon-activated functional rescue.

Source: Molecular Cell - September 30, 2020 Category: Cytology Authors: Judit Carrasco, Michael Rauer, Barbara Hummel, Dominika Grzejda, Carlos Alfonso-Gonzalez, Yeon Lee, Qingqing Wang, Monika Puchalska, Gerhard Mittler, Val érie Hilgers Tags: Short Article Source Type: research