Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex

McDowell et  al. describe structures of the GET insertase bound to the Get3 cytoplasmic chaperone. They reveal that membrane insertion of tail-anchored proteins by Get1/Get2 homologs requires the concerted action of a lipid-stabilized heterotetramer, a conserved cytoplasmic helix α3′, and a membrane-embedde d hydrophilic groove.

Source: Molecular Cell - September 8, 2020 Category: Cytology Authors: Melanie A. McDowell, Michael Heimes, Francesco Fiorentino, Shahid Mehmood, Ákos Farkas, Javier Coy-Vergara, Di Wu, Jani Reddy Bolla, Volker Schmid, Roger Heinze, Klemens Wild, Dirk Flemming, Stefan Pfeffer, Blanche Schwappach, Carol V. Robinson, Irmgard Tags: Article Source Type: research