Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor

Su et  al. report the cryo-EM structure of the complex of isoproterenol-bound β1-adrenergic receptor and heterotrimeric Gs-protein. The structural and functional studies reveal insights into the activation of Gs by β1-adrenergic receptor. This work advances our understanding of the control of heart rat e and contractility by the nervous system and hormones.

Source: Molecular Cell - August 18, 2020 Category: Cytology Authors: Minfei Su, Lan Zhu, Yixiao Zhang, Navid Paknejad, Raja Dey, Jianyun Huang, Ming-Yue Lee, Dewight Williams, Kelsey D. Jordan, Edward T. Eng, Oliver P. Ernst, Joel R. Meyerson, Richard K. Hite, Thomas Walz, Wei Liu, Xin-Yun Huang Tags: Article Source Type: research