Histone Deacetylase 3 Couples Mitochondria to Drive IL-1 β-Dependent Inflammation by Configuring Fatty Acid Oxidation

Mitochondrial adaptations have been intimately linked to acute and chronic inflammation, but the metabolic cues and precise mechanisms remain unclear. Chi et  al. show that HDAC3 translocates to mitochondria to deacetylate the FAO enzyme HADHA for optimal NLRP3 inflammasome activation.

Source: Molecular Cell - September 14, 2020 Category: Cytology Authors: Zhexu Chi, Sheng Chen, Ting Xu, Wenxuan Zhen, Weiwei Yu, Danlu Jiang, Xingchen Guo, Zhen Wang, Kailian Zhang, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Qizhen Ye, Xuyan Yang, Hui Lin, Fan Yang, Xue Zhang, Di Wang Tags: Article Source Type: research